Alessia Bottos

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Universitätsspital Basel, Diagnostische Hämatologie
Cancer immunotherapy, with a special focus on NK cell adoptive transfer for the treatment of Hematologic tumors.
1) Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models.” Bottos A, Gotthardt D, Gill JW, Gattelli A, Frei A, Tzankov A, Sexl V, Wodnar-Filipowicz A, Hynes NE. Nat Commun. 2016 Jul 13;7:12258. doi: 10.1038/ncomms12258. 2) “Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells.” Chiovaro F, Martina E, Bottos A, Hynes NE, Chiquet-Ehrismann R. Int J Cancer. 2015 Apr 13. doi: 10.1002/ijc.29565. [Epub ahead of print] 3) “Cancer: Staying together on the road to metastasis.” Bottos A, Hynes NE. Nature. 2014 Oct 16;514(7522):309-10. doi: 10.1038/514309a. 4) “Memo has a novel role in S1P signaling and crucial for vascular development.” Kondo S, Bottos A, Allegood JC, Masson R, Maurer FG, Genoud C, Kaeser P, Huwiler A, Murakami M, Spiegel S, Hynes NE. PLoS One. 2014 Apr 8;9(4):e94114. doi: 10.1371/journal.pone.0094114. eCollection 2014. 5) “Oncogenes and angiogenesis: a way to personalize anti-angiogenic therapy?” Bottos A, Bardelli A. Cell Mol Life Sci. 2013 Nov;70(21):4131-40. doi: 10.1007/s00018-013-1331-3. Epub 2013 May 18. 6) “Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.” Bottos A, Martini M, Di Nicolantonio F, Comunanza V, Maione F, Minassi A, Appendino G, Bussolino F, Bardelli A. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):E353-9. doi: 10.1073/pnas.1105026109. 7) “Neurexins and neuroligins: synapses look out of the nervous system.” Bottos A, Rissone A, Bussolino F, Arese M. Cell Mol Life Sci. 2011 Aug;68(16):2655-66. doi: 10.1007/s00018-011-0664-z 8) “The synaptic proteins Neurexins and Neuroligins are widely expressed in the vascular system and contribute to its functions.” Bottos A., Destro E., Rissone A., Graziano S. Assenzio B., Cordara G., Cera MR., Mascia L., Bussolino F., Arese M. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20782-7.