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University of Fribourg
The main research interest of the laboratory is the study of tumor-host interactions. We are particularly interested in understanding how the growing tumor modify normal tissue to its advantage, how this modify tissue contribute to tumorigenesis and how therapeutic interventions modify this cross-talk, and what are the consequences. More specifically we are investigating the following aspects of tumor - host interaction: - Tumor microenvironment: How do cells of the microenvironment, in particular bone marrow-derived cells, promote tumor growth and metastasis? How do therapeutic interventions modify the tumor microenvironment and how do these modifications impact tumor behavior? - Tumor angiogenesis: how does tumor angiogenesis modulate tumor dormancy, tumor growth and metastasis? How can we therapeutically exploit this tumor cell - endothelial cell interaction? - Tumor metastasis: How does the cross-talk between tumor cells and the microenvironment evolve during tumor metastasis ? - Understanding how tumors adapt and evade anticancer therapies. How do tumors and the microenvironment react to anticancer therapies and what are the consequences to tumor progression ?
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